The Morphologic Effects of Oral Contraceptive Agents on the Cervix
- 24 March 1969
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 207 (12) , 2243-2247
- https://doi.org/10.1001/jama.1969.03150250073006
Abstract
Clinical evaluation of the pelvis, Papanicolaou smears, and histologic review of cervical biopsy specimens in 103 patients were used to study the effects of oral contraceptive agents on the cervix. No patient was found to have carcinoma, but a clinical lesion was present in 84% of the patients. Reactivity of the cervix to contraceptive agents as judged by several histologic criteria increases as continuous use of the contraceptive agent increases; however, cervical reactivity is decreased in older women. Combination contraceptive agents caused greater histologic change than sequential agents.Keywords
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