Characterization of the Antibody Response to Type III Pneumococcal Polysaccharide at the Cellular Level

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Abstract
A plaque-inhibition test was used to assess the relative avidity of the IgM antibody specific for type III pneumococcal polysaccharide (SSS-III). No changes in avidity were demonstrable at various times after immunization and over a 20,000-fold range of antigen dose. Prior immunization, regardless of the dose of SSS-III employed, resulted in no change in avidity. These results indicated that a restricted population of lymphoid cells participates in the antibody response to SSS-III and that an antigen-mediated cell selection process does not play a significant role.

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