Diaziquone, 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone, plasma and cerebrospinal fluid kinetics
- 1 May 1982
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 31 (5) , 650-655
- https://doi.org/10.1038/clpt.1982.90
Abstract
Plasma and CSF kinetics of [the antineoplastic drug] diaziquone, (2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone; AZQ), were evaluated after i.v. injection in patients with implanted Ommaya reservoirs. After a 30 min infusion plasma disappearance was very rapid, with a disposition half-life of 2-6 min and an elimination half-life of 25-35 min. Area under the concentration-time curve for CSF was 22%-42% of the corresponding plasma area. Based upon total plasma AZQ concentration, volume of distribution for AZQ was 2.0-10.0 l/m2. Plasma binding of AZQ was 79% in 1 normal subject. When the effect of plasma binding is considered, distribution volumes are more plausible; it appears that free plasma AZQ is completely available to the CSF.This publication has 2 references indexed in Scilit:
- Potential CNS Antitumor Agents VI: Aziridinylbenzoquinones IIIJournal of Pharmaceutical Sciences, 1979
- Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 2Journal of Medicinal Chemistry, 1976