Further Studies on the Inhibitory Effect of Vitamin A on the Development of Ovary-Independent Vaginal Cornification in Neonatally Estrogenized Mice

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Abstract
In ovariectomized adult C57 Black/MS mice which had been given daily injections of 20μg estradiol for 5 days from the day of birth, the vaginal epithelium underwent persistent hyperplasia and cornification. However, the vaginal epithelium of ovariectomized adult mice receiving 5 daily injections of 20μg estradiol concurrently with 100 I.U. vitamin A acetate was atrophic, like that of ovariectomized mice given daily injections of either vitamin A alone or the vehicle (sesame oil) during the same neonatal period. In ovariectomized adult mice which had been given 5 daily injections of 20μg estradiol from the day of birth and 5 daily injections of 100 I.U. vitamin A from the 6th day on, the vaginal epithelium was stratified and cornified as in mice receiving neonatal injections of estradiol only.