Elevated Cerebrospinal Fluid Sulfatide Concentrations as a Sign of Increased Metabolic Turnover of Myelin in HIV Type I Infection
- 20 January 1996
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 12 (2) , 149-155
- https://doi.org/10.1089/aid.1996.12.149
Abstract
Cerebrospinal fluid (CSF) sulfatide concentrations were analyzed in 18 patients with asymptomatic HIV-1 infection, in 16 patients with AIDS who were free from opportunistic infections in the central nervous system (CNS), in 12 HIV-1-infected patients with opportunistic CNS infections or lymphoma, and in 19 HTV-negative controls, by thin-layer chromatography overlay technique using an antisulfatide antibody to estimate the metabolic turnover of myelin. The majority of asymptomatic HIV-1-infected patients had normal CSF sulfatide concentrations, but the mean CSF sulfatide concentration was still elevated compared to that in HIV-negative controls (152 compared to 99 nmol/liter, p < 0.05). The CSF sulfatide concentrations in the AIDS group (mean 395 nmol/liter) were significantly increased compared to those in asymptomatic HIV-1-infected patients (p < 0.01) and in HIV-negative controls (p < 0.001), but did not differ significantly between patients with and without dementia. Increased CSF sulfatide concentrations were also found in patients with opportunistic infection or lymphoma in the CNS. In the entire study population, the sulfatide levels were associated with blood–brain barrier function, but not with intrathecal immunoglobulin production or with positive HIV isolations from CSF. Thus, signs of white matter changes, measured as increased CSF sulfatide concentrations, could be found in some asymptomatic HIV-1-infected patients, but the highest levels were seen in patients with AIDS.Keywords
This publication has 34 references indexed in Scilit:
- Cytomegalovirus infection of the CNS in non-compromised patientsActa Neurologica Scandinavica, 2009
- Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood‐brain barrierAnnals of Neurology, 1993
- Sulfatide as a biochemical marker in cerebrospinal fluid of patients with vascular dementiaActa Neurologica Scandinavica, 1992
- Decreased myelin lipids in Alzheimer's disease and vascular dementiaActa Neurologica Scandinavica, 1989
- Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1AIDS, 1989
- The AIDS Dementia ComplexThe Journal of Infectious Diseases, 1988
- Isolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1985
- The structure of the major immediate early gene of human cytomegalovirus strain AD169Virus Research, 1985
- Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference valuesScandinavian Journal of Clinical and Laboratory Investigation, 1977
- Cell surface shedding—The phenomenon and its possible significanceJournal of Theoretical Biology, 1976