PATHOLOGICAL CHANGES OF THE LIVER IN LEC RATS WITH HEREDITARY HEPATITIS
Open Access
- 1 January 1988
- journal article
- Published by Japanese Society of Toxicologic Pathology in Journal of Toxicologic Pathology
- Vol. 1 (1) , 53-60
- https://doi.org/10.1293/tox.1.53
Abstract
Recently a new mutant causing hereditary hepatitis was established from non-inbred Long-Evans rats. Hepatitis with severe jaundice appears spontaneously in rats 4 months after birth. Some affected rats die of submassive hepatic necrosis, while others survive for a long life. Liver cancers appear in these long survived rats. The hereditary hepatitis rats thus provide an animal model useful for the basic and clinical studies of hepatitis and liver cancer.Keywords
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