A phase II study of ifosfamide in advanced and relapsed carcinoma of the cervix
- 1 December 1986
- journal article
- research article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 18 (3) , 280-283
- https://doi.org/10.1007/bf00273403
Abstract
Summary Forty-one patients with advanced progressing carcinoma of the cervix were treated with ifosfamide 1.5 g/m2 daily in a 30-min infusion for 5 days every 3 weeks. The overall response rate (complete + partial) was 12/39 (31%), or 12/30 (40%) in those who had not received previous chemotherapy. Six patients achieved a complete remission of disease and four of these remain disease-free 24–39 months later. Durable response were seen in patients with disease progressing after radical radiotherapy. Bone marrow suppression was the dose-limiting toxicity and led to dosage modification in 24 patients. Nausea and vomiting was experienced by all patients at some time during therapy and all patients developed alopecia. Mild neurological toxicity occurred in seven patients but severe life-threatening neurotoxicity was not seen with this schedule of administration. Further studies are needed to identify the optimum dose and schedule of ifosfamide and to ascertain its place in combination therapy.Keywords
This publication has 12 references indexed in Scilit:
- ENCEPHALOPATHY ASSOCIATED WITH IFOSPHAMIDE/MESNA THERAPYThe Lancet, 1985
- Cervical carcinoma: A drug-responsive tumor—experience with combined cisplatin, vinblastine, and bleomycin therapyGynecologic Oncology, 1983
- High-dose ifosfamide by infusion with mesna in advanced soft tissue sarcomaCancer Treatment Reviews, 1983
- Ifosfamide in the treatment of extensive non-oat cell carcinoma of the lung.1982
- The anticancer spectrum of ifosfamide.1982
- Central nervous side effects following ifosfamide monotherapy of advanced renal carcinomaZeitschrift für Krebsforschung und Klinische Onkologie, 1981
- PREVENTION OF ISOPHOSPHAMIDE-INDUCED UROTHELIAL TOXICITY WITH 2-MERCAPTOETHANE SULPHONATE SODIUM (MESNUM) IN PATIENTS WITH ADVANCED CARCINOMAThe Lancet, 1980
- LONG TERM RESULTS OF TREATMENT OF CARCINOMA OF CERVIXBJOG: An International Journal of Obstetrics and Gynaecology, 1980
- Carcinoma of the cervix at the Royal Marsden Hospital, London 1962–70:survival resultsThe British Journal of Radiology, 1979
- Results obtained with fractionated ifosfamide massive-dose treatment in generalized malignant tumours.1976