Dynamics of cytotoxic T–lymphocyte exhaustion
Open Access
- 7 February 1998
- journal article
- Published by The Royal Society in Proceedings Of The Royal Society B-Biological Sciences
- Vol. 265 (1392) , 191-203
- https://doi.org/10.1098/rspb.1998.0282
Abstract
Diffraction gratings are reported from external surfaces of the hard, protective parts of Wiwaxia corrugata, Canadia spinosa and Marrella splendens from the Burgess Shale (Middle Cambrian (515 million years), British Columbia). As a consequence, these animals would have displayed iridescence in their natural environment: Cambrian animals have previously been accurately reconstructed in black and white only. A diversity of extant marine animals inhabiting a similar depth to the Burgess Shale fauna possess functional diffraction gratings. The Cambrian is a unique period in the history of animal life where predatory lifestyles and eyes capable of producing visual images were evolving rapidly. The discovery of colour in Cambrian animals prompts a new hypothesis on the initiation of the ‘Big Bang’ in animal evolution which occurred during the Cambrian: light was introduced into the behavioural systems of metazoan animals for the first time. This introduction, of what was to become generally the most powerful stimulus in metazoan behavioural systems, would have triggered turbulence in metazoan evolution.Keywords
This publication has 97 references indexed in Scilit:
- Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cellsImmunology Today, 1996
- Immune Defence in Mice Lacking Type I and/or Type II Interferon ReceptorsImmunological Reviews, 1995
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995
- Viral dynamics in human immunodeficiency virus type 1 infectionNature, 1995
- T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDSImmunology Today, 1994
- T-cell toleranceCurrent Opinion in Immunology, 1993
- Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T CellsImmunological Reviews, 1993
- Coexistence and competition in HIV infectionsJournal of Theoretical Biology, 1992
- Antigenic Diversity Thresholds and the Development of AIDSScience, 1991
- Viruses Perturb Lymphocyte Functions: Selected Principles Characterizing Virus-Induced ImmunosuppressionAnnual Review of Immunology, 1987