Improving the Prediction of Coronary Heart Disease to Aid in the Management of High Cholesterol Levels

Abstract
THE NATIONAL Cholesterol Education Program (NCEP) has recognized the importance of risk-based guidelines in its policies regarding the treatment of high blood cholesterol levels for the prevention of coronary heart disease (CHD).1 The logic underlying this strategy is 2-fold.2 First, individuals at lower risk of CHD have less likelihood of benefiting from cholesterol-reducing medical therapy but are at the same risk of potential adverse medication effects as higher-risk patients.3 Second, the cost-effectiveness of lipid-reducing therapy is greater when treatment is targeted toward individuals at higher risk.4