CLINICAL TRIAL WITH AMANTADINE AND PEMOLINE IN ELDERLY PATIENTS
- 1 February 1976
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Age and Ageing
- Vol. 5 (1) , 6-11
- https://doi.org/10.1093/ageing/5.1.6
Abstract
In a controlled clinical trial, amantadine 400 mg daily, 200 mg daily and 200 mg daily given with 20 mg of pemoline daily were compared with placebo in the treatment of elderly patients suffering from involutional cerebropathy characterized by psychomotor slowing down. The results showed that amantadine 400 mg daily was superior to placebo but was associated with a high incidence of side-effects (37 per cent), amantadine 200 mg daily was not superior to placebo but when pemoline 20 mg daily was added the combination was superior to placebo and few side-effects were reported.Keywords
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