Sarcomere length during post-natal growth of mammalian muscle fibres

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Abstract
The length of the sarcomeres, the A- and the I-filaments and their percentage overlap were measured in the fibres of the biceps brachii muscle from mice of different ages. The sarcomere length with the limb in the fully extended position was found to increase from 2·3 μ in the newborn animal to 2·8 μ in the adult. This increase was due to a decrease in the percentage overlap of the filaments and not to any change in the filament lengths. The sarcomeres at the ends of the fibres were found to be shorter than those in the middle of the muscle, at all ages. When the muscles were stretched beyond their resting length, only about the middle 60 % of the sarcomeres in the young muscles increased in length. Length/tension plots were obtained for young and old muscles and the difference in the shape of these plots could be explained as being due to the non-functional terminal sarcomeres of the young muscles. The maximum tension developed by the young muscles was found to be attained at an initial muscle length about 10 % greater than their length at maximum limb extension. The adult muscles developed maximum tension at their length at maximum limb extension.