Relation between structure and cholinergic activity. I. Synthesis and muscarinic activity of 5‐alkyl‐2‐methyl‐4‐trimethylammoniomethyl‐1,3‐dioxolane iodides

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Abstract
The preparation and muscarinic activities of a number of 5‐alkyl substituted analogues of the dioxolane of Fourneau are described. Muscarinic activity decreases rapidly when the alkyl chain lengthens, moreover a change from parasympathomimetic into parasympatholytic activity occurs. The stereochemical aspects with regard to the 5‐position are considered. The synthesis and cholinolytic effect of 2‐methyl‐c‐5‐propyl‐r‐4‐trimethylammoniomethyl‐1,3‐dioxolane iodide and the corresponding 4,5‐trans compound are described.