The influence of Tigason' (Ro 10–9359) on the serum lipoproteins in man

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Abstract
Patients (8) with psoriasis or Darier''s disease were studied during 1-3 mo. of Tigason treatment (0.7-0.8 mg/kg body wt). The levels of triglycerides and cholesterol in whole serum and in different lipoprotein fractions were determined. Before treatment all lipid values were within the normal range. During treatment the values changed gradually and 5 of the 8 patients developed pathological VLDL [very low density lipoprotein] triglyceride concentrations. A significant increase of VLDL cholesterol and a decrease in the HDL [high density lipoprotein] cholesterol was also noted. Until more information is available, prolonged treatment periods with Tigason should be avoided, at least in high risk patients.