Specificity of Resistance to Tuberculosis and to Salmonellosis Stimulated in Mice by Oil-Treated Cell Walls

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Abstract
Coating with oil, which was essential to render cell walls of BCG protective to mice against challenge with tubercle bacilli by aerosol, has been found not to affect the specificity of reactions conditioned by cell walls in this and other systems. When the interval between vaccination and challenge was short (24 hr.), mice were protected against heavy intravenous challenge with Mycopacterium tuberculosis principally by nonspecific factors; after a 30-day interval, protection appeared to depend upon a mixture of specific and nonspecific effects.