Kernicterus in Rats with an Inherited Deficiency of Glucuronyl Transferase

1 May 1959

journal article
research article
Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine

Vol. 97 (5_PART_I) , 591-608
https://doi.org/10.1001/archpedi.1959.02070010593009

Abstract

This paper describes the occurrence of kernicterus and factors which influence its development in the strain of rats * first studied by Gunn.^22,23The disease of humans designated in 1903 by Schmorl³⁹as kernicterus has, in our opinion, not been observed or induced in its entirety in animals. Various workers, however, have demonstrated the toxicity of indirect bilirubin.^{12-15,24,26,44-46}Ernster, Herlin, and Zetterström²¹have caused localized pigmentation of the brain of the rabbit by treatment with bilirubin and an S-H blocking agent. Other workers^17,19,20have reported injury of brain tissue in hemolytic anemia of animals, a phenomenon not directly related to the present report, since the rats to be described do not suffer from antibody-antigen disease and have little or no hemolytic Definition of Kernicterus The following criteria are proposed as defining kernicterus: Distinctive evidence of central nervous system dysfunction during life in jaundiced subjects Canary yellow

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