In Vivo Acquisition of High-Level Resistance to Imipenem inEscherichia coli
Open Access
- 1 August 2004
- journal article
- case report
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 42 (8) , 3831-3833
- https://doi.org/10.1128/jcm.42.8.3831-3833.2004
Abstract
Four clonally related Escherichia coli strains were isolated successively from bile duct of a girl suffering from sclerosing cholangitis. One of them, selected after an imipenem-containing regimen, was resistant to carbapenems and to broad-spectrum cephalosporins due to a plasmid-mediated cephalosporinase, CMY-2, and the lack of outer membrane proteins OmpF and OmpC.Keywords
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