Detection of endotoxin in cerebrospinal and joint fluids by limulus assay
- 1 January 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 137 (1) , 55-56
- https://doi.org/10.1001/archinte.137.1.55
Abstract
Cerebrospinal fluid (CSF) and joint fluid from 81 patients were studied for the presence of endotoxin using the limulus assay. All fluids that grew Gram-negative organisms had a positive limulus test. However, one sample of CSF and one of joint fluid, both very purulent, that contained Gram-positive organisms also gave positive limulus assays. All culturally negative fluids had a negative limulus assay. Thus, a positive limulus assay with CSF or joint fluid is indicative of bacterial infection probably caused by Gram-negative organisms and can be an extremely useful diagnostic adjunct. (Arch Intern Med137:55-56, 1977)This publication has 1 reference indexed in Scilit:
- Gram-Negative Sepsis: Detection of Endotoxemia with the Limulus TestAnnals of Internal Medicine, 1972