Cerebral Vascular Abnormalities in a Murine Model of Hereditary Hemorrhagic Telangiectasia
- 1 March 2003
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 34 (3) , 783-789
- https://doi.org/10.1161/01.str.0000056170.47815.37
Abstract
Background and Purpose— Hereditary hemorrhagic telangiectasia type 1 (HHT1) is an autosomal dominant vascular dysplasia caused by mutations in the endoglin gene and characterized by dilated vessels and arteriovenous malformations (AVMs). To understand the etiology of this disorder, we evaluated the cerebral vasculature of endoglin heterozygous (Eng+/−) mice, which represent the only animal model of HHT1. Methods— The cerebral vasculature of Eng+/− and Eng+/+ mice from C57BL/6 (B6) and 129/Ola (129) strains with a differential susceptibility to HHT1 was studied with corrosion casting. Casts were observed by scanning electron microscopy to detect malformations and evaluate arterial diameters and orientation of endothelial nuclei. Measurements were taken to assess relative constriction at arteriolar branching points and downstream relative dilatation. Results— Three of 10 Eng+/− mice demonstrated abnormal vascular findings including AVMs, while none of 15 Eng+/+ mice did. The incidence of relative constricti...Keywords
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