THE SHEEP ANALOG OF LEUKOCYTE COMMON ANTIGEN (LCA)

  • 1 January 1985
    • journal article
    • research article
    • Vol. 55  (2) , 347-353
Abstract
The tissue distribution and immunochemical properties of antigens recognized by 2 monoclonal antibodies, 1.11.32 and 1.28.124, define the sheep analog of the leukocyte common antigen found in rat, man and mouse. Histological and immunofluorescent studies show that this antigen is found on all lymphocytes, as well as other leukocytes but is absent from non-leukocytic cells. Immunochemical data show that a series of proteins of high MW (190,000-225,000) are recognized, and histological studies show the presence of this antigen on a subpopulation of fetal liver cells as early as Day 27-30 of gestation, and on all fetal thymocytes from Day 40 of gestation.

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