Cigarette Smoking Increases Gastric Luminal Prostaglandin F2α and Thromboxane B2 in Healthy Smokers

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Abstract
Pentagastrin-stimulated gastric luminal prostaglandin E2 (PGE2), 6-keto-PGF1α, PGF2α and thromboxane B2 (TxB2) were measured using a second antibody solid-phase enzyme immunoassay before, during and after cigarette smoking in healthy smokers. Smoking significantly increased PGF2α and TxB2 concentration and output; in contrast no significant changes were found for PGE2 and 6-keto-PGF1α levels. In addition, cigarette smoking caused a significant reduction in gastric juice volume and acid output but did not alter intragastric acidity. These findings may suggest a possible role of prostanoids in the response of the stomach to cigarette smoking.