Dissociated expression of c-myc and a fos-related competence gene during cardiac myogenesis.
Open Access
- 1 November 1986
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 6 (11) , 4140-4143
- https://doi.org/10.1128/mcb.6.11.4140
Abstract
Cardiac myocytes irreversibly lose their proliferative capacity soon after birth, and cardiac DNA synthesis becomes uncoupled from mitotic division. Therefore, we examined cardiac muscle for developmental down regulation of inducible proto-oncogenes associated with cell proliferation. c-myc mRNA decreased continuously from day 13 of embryonic development and was dissociated from expression of the fos-related gene r-fos, which decreased precipitously between days 3 and 7 after birth.This publication has 40 references indexed in Scilit:
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