Application of polylysine bound succinyl‐NA to a membrane reactor

Abstract
The amide bond at N‐6 in succinyl‐NAD was found to be more stable than in former accounts. Succinyl‐NAD was coupled on polylysine to give a new polymer derivative of NAD, which retained at least 85% of the initial coenzymic activity even after dialysis for one week. The polymer derivative of NAD could be applied to a membrane reactor containing alcohol dehydrogenase and lactate dehydrogenase and lactate was continuously produced in a half‐life of ten days.