Keloid fibroblasts in culture: Abnormal growth behaviour and altered response to the epidermal growth factor
- 1 April 1989
- journal article
- research article
- Published by Wiley in Cell Biology International Reports
- Vol. 13 (4) , 325-335
- https://doi.org/10.1016/0309-1651(89)90159-8
Abstract
Keloid fibroblasts were propagated in culture and their proliferative behaviour and response to the Epidermal Growth Fctor (EGF) were studied. Keloid fibroblasts grew at a rate which was approximately one-half that of normal age, sex and race matched control fibroblasts. Keloid fibroblasts were stimulated to grow in the presence of EGF (10 ng/ml), but to a lesser degree than the normal control fibroblasts. Scatchard analysis of the binding data obtained using 125I-labeled EGF revealed no difference in binding affinity or receptor numbers between keloid and normal fibroblasts.This publication has 2 references indexed in Scilit:
- Alteration of amino acid transport by hydrocortisone. Different effects in human fibroblasts derived from normal skin and keloid.Journal of Biological Chemistry, 1982
- Human epidermal growth factor/urogastrone: Rapid purification procedure and partial characterizationAnalytical Biochemistry, 1981