Pathology of Non-Effusive Type Feline Infectious Peritonitis and Experimental Transmission

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Abstract
Cases (7) of feline infectious peritonitis (FIP) clinically diagnosed as noneffusive type were examined histopathologically. Most lesions were similar to those of effusive type of FIP, showing necrosis with vasculitis and granulomatous inflammation in the kidneys, liver, mesenteric lymph nodes, lungs, brain and eyes. After inoculation with emulsion of materials from 1 of the natural cases, effusive and noneffusive types of FIP were produced in 10 and 2 kittens, respectively. Histopathology and EM of the naturally occurring and experimentally induced cases revealed viral growth in large mononuclear cells at early stages of infection prior to formation of necrotic lesions.