Phenolic cyclisation. Part X. Isoquinoline cyclisation under basic conditions
- 1 January 1971
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 2632-2634
- https://doi.org/10.1039/j39710002632
Abstract
The treatment of 3-hydroxy-N-methylphenethylamine (5) with benzaldehyde, 4-chlorobenzaldehyde, phenylpropionaldehyde, cyclohexanone, and cyclopentanone in ethanol afforded the corresponding 1-aryl- and 1-spirocyloalkano-1,2,3,4-tetrahydro-2-methylisoquinolines(7), (8), (9), (11), and (12), respectively. Furthermore, the above isoquinoline cyclisation was found to occur in basic media such as pyridine and triethylamine.Keywords
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