CANCER IN A GROUP AT RISK OF ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) THROUGH 1984

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Abstract
Blggar, R. J. (National Cancer Institute, NIH, Bethesda, MD 20892), J. Horm, J. J. Goedert, and M. Melbye. Cancer in a group at risk of acquired immunodeficiency syndrome (AIDS) through 1984. Am J Epidemiol 1987; 126:578–86. Using a proportional morbidity analysis method, the authors examined changes in the risk of malignancy among never-married men 20–49 years old (a surrogate population for homosexual men) in a high AIDS-risk area (City of San Francisco) and other lower AIDS-risk areas. This approach easily detected increases in Kaposi's sarcoma (odds ratio (OR) comparing 1973–1978 to 1984: 2,479-fold, proportional increase = 99.9%) and in non-Hodgkin's lymphomas (OR = 4.2-fold in 1984, p for trend p for trend = 0.13) and for hepatoma (p for trend = 0.08). A posteriori, the authors noted increases in urinary tract tumors and acute lymphoblastic leukemia which warrant monitoring. Other tumors suggested to be AIDS-associated did not occur excessively in this population. Among single young men outside of San Francisco, Kaposi's sarcoma also increased significantly (OR = 182 in 1984), suggesting a lag of about three years behind the increases in the City of San Francisco. Some tumors may require a longer latent period before an association becomes manifest. in the meantime, however, these data indicate that the increases in AIDS-related cancers are limited to only a few malignancies.

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