Synthesis of Dicarboxylic Monoesters with Cyclic Anhydrides under High Pressure
- 1 June 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (06) , 650-652
- https://doi.org/10.1055/s-1995-5033
Abstract
The reaction of sterically hindered alcohols with cyclic anhydrides in pyridine in the presence of N,N-dimethylaminopyridine (DMAP) under high pressure directly afforded the dicarboxylic monoesters in high yields. The present method was successfully applied to the synthesis of the 2’,7-dihemiesters of taxol as water-soluble prodrugs.Keywords
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