Dietary Protein Levels, Vitamins, and Lactose on Depressant Effect of Sulfadrugs on Urinary and Liver Ascorbic Acid in the Rat

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Abstract
Summary 1. The adverse effect of sulfadrugs on urinary excretion of ascorbic acid in the rat and its counteraction by high levels of dietary protein have been substantiated. 2. Lactose, known to enhance proliferation of intestinal microflora, did not in itself raise ascorbic acid levels in the liver or urine when added to high and low protein diets at 10% level. However, it abolished the adverse effects of the sulfadrugs at 2% level which again was reversed by increasing the sulfadrug level to 4%. 3. Supplementation of the diet with all the known vitamins failed to reverse the effect of the sulfadrug.

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