Dose Effect Relationship for Epilation and Late Effects on Spinal Cord in Rats Exposed to Gamma Rays

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Abstract
The response of rat spinal cords (T7-T12) exposed to single and multifractionated .gamma.-ray exposures revealed no significant differences between the threshold doses for 2 fractions given with a 24 h interval and 2 fractions given with a 15 day interval. The latent period for spinal cord damage was about 190 days when the incidence of paralysis was high; it was less than this in animals with a lower probability of paralysis. There was a marked sparing effect from dose fractionation: the initial part of a Strandqvist type of isoeffect curve had a slope of 0.44 for doses causing paralysis in 50% of the animals and 0.36 for threshold doses. The level of epilation was not useful for predicting spinal cord damage.

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