Reciprocal Lymphoid Cell Homing Studies Using Wild and LPR (Lymphoproliferation) Mutant C57Bl MICE

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Abstract
The injection of lymphoid cells from adult Ipr mice into normal and athymic congenic mice does not transfer the Ipr (lymphoproliferation) syndrome1, We studied whether this phenomenon could be due to abnormal homing. The lymphoid cells from Ipr donors do not show a marked deficiency of migration to lymphoid organs in comparison with cells from Wild donors and a T-cell lymphona BL/VL3. The lymphoid organs of Ipr recipients do not show an intrinsic abnormality as homing sites for lymphoid cells. The data reveal some minor migration preferences: the Ipr cells migrate better than Wild cells into Ipr lymph nodes (including athymic Ipr hosts), whereas Wild cells migrate slightly better than Ipr cells into Wild lymph nodes. In spite of such minor preferences, Wild cells can efficiently migrate into Ipr lymphoid organs, as well as Ipr cells into Wild lymphoid organs. Thus, the lack of transfer of lymphadenopathy in Wild recipients cannot be attributed to an alteration of Ipr cell homing.