Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase
- 1 June 1991
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 47 (6) , 616-619
- https://doi.org/10.1007/bf01949888
Abstract
The inhibitory potencies of different flavonoids for rat liver cytosolic glutathione S-transferase activity varied over 30-fold, depending on the pattern of hydroxylation, the presence of a C-2, C-3 double bond and the substitution of a hydroxyl group with a sugar moiety. Kinetic inactivation studies of the enzyme with the inhibitor quercetin revealed a non-competitive profile versus both glutathione and 1-chloro-2,4-dinitrobenzene.Keywords
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