Thiamine Release from Nerve Membranes by Tetrodotoxin
- 7 November 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3906) , 759-761
- https://doi.org/10.1126/science.166.3906.759
Abstract
Tetrodotoxin (3 x 10-8 molar) promoted the release of thiamine from perfused rat and frog nerve preparations in a manner similar to other neuroactive drugs. When the rats were injected with thiamine labeled with sulfur-35, analyses of brain, spinal cord, and sciatic nerve homogenates revealed labeled thiamine in membrane, synaptosomes, and mitochondrial subfractions. However, on incubation of these fractions with tetrodotoxin, thiamine was released only from the membrane fragments.Keywords
This publication has 10 references indexed in Scilit:
- Ion movements and thiamine in nervous tissue—I Intact nerve preparationsBiochemical Pharmacology, 1970
- Enzyme‐inhibiting factor in subacute necrotizing encephalomyelopathyNeurology, 1969
- Thiamine Triphosphate Deficiency in Subacute Necrotizing EncephalomyelopathyScience, 1969
- On a relationship between ion transport and thiamine in nervous tissueBiochemical Pharmacology, 1969
- THE FLUORESCENT MICROSCOPIC LOCALIZATION OF THIAMINE IN NERVOUS TISSUEJournal of Histochemistry & Cytochemistry, 1968
- The enzymatic synthesis of triphosphotiaminBiochimica et Biophysica Acta (BBA) - General Subjects, 1968
- The role of thiamine nervous tissue: The mechanism of action of pyrithiamineBiochimica et Biophysica Acta (BBA) - General Subjects, 1968
- Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant AxonsThe Journal of general physiology, 1964
- Biochemical and Physiological Function of Thiamine in Nervous TissueNature, 1963
- The isolation and characterization of acetylcholine-containing particles from brainBiochemical Journal, 1959