Differential effects of septal, preoptic, and habenula ablations on thirst-motivated behaviors in rats.

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Abstract
Two experiments used a total of 59 male Sprague-Dawley rats. Bilateral septal lesions dramatically enhanced barpressing rates generated under progressive ratio schedules of reinforcement. This increased barpressing was dependent on deprivation level but independent of the type of deprivation (i.e., food or water). Equivalent effects on barpressing were observed in Ss with bilateral medial forebrain bundle lesions at the level of the lateral preoptic area. Septal lesions, medial forebrain bundle lesions, and habenula lesions did not result in a hyperreactivity to bitter quinine solutions. Hyperreactivity to quinine was observed only in Ss with medial preoptic lesions. This medial preoptic lesion also impaired operant responding for water on a progressive ratio schedule of reinforcement. It is suggested that the medial preoptic lesion produced a deficit in thirst-motivated behavior. (16 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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