ACTIVITY OF BEPRIDIL AND OTHER ANTI-ANGINALS ON CARDIOVASCULAR MODIFICATIONS ENGENDERED BY CONDITIONED ANXIETY IN DOG

  • 1 January 1978
    • journal article
    • research article
    • Vol. 235  (1) , 147-164
Abstract
The action of bepridil (5 mg/kg), perhexiline (5 mg/kg), propranolol (0.5 mg/kg), dipyridamole (0.5 mg/kg), amiodarone (10 mg/kg), pentaerythritol tetranitrate (40 .mu.g/kg) and nitroglycerine (40 .mu.g/kg) on cardiovascular manifestations of auditory-induced emotional stress has been investigated in the conscious dog. Bepridil, perhexiline and propranolol considerably reduce tachycardia provoked by the anxiogenic stimulus, with nitroglycerin exerting an attenuated effect and the others with no significant effect on this parameter. Bepridil, nitroglycerin, perhexiline, propranolol and pentaerythritol all significantly reduce the elevation of the Robinson index, the first 4 with the same intensity. Only amiodarone and dipyridamole are without effect on this parameter of cardiac workload. None of the products under investigation significantly reduces systolic hypertension, associated with the induction of conditioned anxiety.

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