A COMPARISON OF OXITROPIUM BROMIDE AND IPRATROPIUM BROMIDE IN ASTHMA

  • 1 January 1984
    • journal article
    • research article
    • Vol. 65  (2) , 106-108
Abstract
Oxitropium bromide [OB] is a derivative of scopolamine and is an anticholinergic drug. Twenty asthmatics completed the study in which they received, in randomized double-blind fashion, placebo, ipratropium bromide [IB] 80 .mu.g, and OB 200 .mu.g. The patients recorded peak expiratory flow [PEF] immediately before inhalation and up to 10 h afterwards. PEF were significantly higher than placebo between 10 min and 10 h, for both active treatments. There were no significant differences between values on OB and IB at any time points. Side effects were minimal. Evidently, OB is an effective bronchodilator in asthma.

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