Vergleich zwischen biochemischer und histochemischer Hormonrezeptorenbestimmung bei Mammakarzinomen

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Abstract
The hormonal sensitivity of breast cancer indicates the prognosis and determines the therapeutical procedure when metastases appear. It also seems to be important in the choice of adjuvant therapy. The analysis of hormonal receptors is at least as important as the histological typification of the carcinoma. As the histochemical steroid-receptor-assay is much less complicated than the biochemical (quantitative) method, the value of this fluorescence-microscopical assay was investigated by means of parallel determinations. In assays from 157 patients the last 3 yr differences in 45% of all estrogen-receptor-determination were found in 50% of 29 progesterone-receptor-determinations. The histochemical assay is most probably not representative. There is serious doubt about the possibility to document the hormone receptor by this method. Therefore it does not seem advisible at the moment to waive the biochemical receptor determination.