PLASMA ANGIOTENSIN II AND ALDOSTERONE EXCRETION DURING THE MENSTRUAL CYCLE

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Abstract
The angiotensin II concentration in the plasma and the urinary aldosterone excretion were measured early in the follicular phase and late in the luteal phase in 9 women with regular menstrual cycles. The plasma angiotensin II in the follicular phase was 1.78 ng/100 ml ± 0.20 (sem) and in the luteal phase 3.12 ng/100 ml ± 0.43 (sem). Values for aldosterone excretion were 10.89 μg/24 h ± 1.43 (sem) and 21.67 μ/24 h ± 2.96 (sem) respectively. Pregnanediol increased from 0.42 mg/24 h ± 0.12 (sem) to 2.0 mg/24 h ± 0.28 (sem) in the same specimens of urine. It is suggested that the observed changes in concentration and excretion of the hormones are sequentially related as follows: The sodium losing effect of progesterone stimulates renin release, giving an increased plasma angiotensin II, which in turn leads to an augmented aldosterone production.

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