ANTAGONISTS OF GLUTAMATE RECEPTORS FROM THE VENOM OF ARGIOPE-LOBATA SPIDER
- 1 July 1988
- journal article
- research article
- Vol. 14 (7) , 883-892
Abstract
Homologous low molecular weight compounds blocking postysynaptic glutamate receptors were isolated from the Argiope lobata spider venom by ion-exchange chromatography and reverse-phase HPLC. Structures of nine different blocking agents were determined by NMR and mass spectroscopy. They can be divided into three groups: argiopin, argiopinins, and pseudoargiopinines. The major principles of the structural organization of the novel class of antagonists of gluctamate receptors were considered.This publication has 2 references indexed in Scilit:
- Improved spectral resolution in COSY 1H NMR spectra of proteins via double quantum filteringBiochemical and Biophysical Research Communications, 1983
- Spider venom contains specific receptor blocker of glutaminergic synapsesBrain Research, 1982