The regulation of pH in the central nervous system
- 15 May 1992
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 70 (S1) , S278-S285
- https://doi.org/10.1139/y92-273
Abstract
The pHi regulation from intracellular acidosis in the central nervous system appears to be mediated by mechanisms driven by the large inwardly directed Na+ gradient. The involvement of these mechanisms in pHi regulation of neurones and glial cells has been investigated in the leech central nervous system using ion-selective microelectrodes. For recovery from acidification, there appear to be three separate mechanisms: Na+/H+ exchange, Na+-dependent Cl−/HCO3− exchange, and Na+–HCO3− cotransport. All three mechanisms have a profound effect on the maintenance of pHi homeostasis in glial ceils; whereas in leech neurones, as in other neuronal cells studied previously, the predominant mechanisms are Na+/H+ and Na+-dependent Cl−/HCO3− exchange. In addition to acid extrusion mechanisms we also found evidence for Na+-independent Cl−/HCO3− exchange. At alkaline pHi this exchanger may mediate some of the pHi recovery from intracellular alkalinization.Key words: central nervous system, pH regulation, neurotransmitter.Keywords
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