Modulation of phosphate accumulation in isolated chick kidney cells by gluconeogenic substrates
- 1 September 1982
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 2 (9) , 661-666
- https://doi.org/10.1007/bf01114827
Abstract
An isolated proximal-tubule preparation is described that accumulates Pi in a saturable, Na+-dependent manner. The initial rate of Pi accumulation is greater in cells incubated with the gluconeogenic substrates pyruvate and lactate than in cells incubated with glucose. Glucose was produced from the substrates under these conditions. Incubation with either NAD+ or NADH inhibits the initial rate of Pi accumulation. Apparently the effects of gluconeogenesis on Pi uptake are not mediated by the oxidation state of the nicotinamide coenzymes.This publication has 11 references indexed in Scilit:
- Hydrolysis of nicotinamide-adenine dinucleotide by purified renal brush-border membranes. Mechanism of NAD+ inhibition of brush-border membrane phosphate-transport activityBiochemical Journal, 1982
- Effect of acetate on transport of organic acid (fluorescein) in renal proximal tubules of frogBiochimica et Biophysica Acta (BBA) - Biomembranes, 1982
- NICOTINAMIDE ADENINE DINUCLEOTIDE AND RENAL RESPONSE TO PARATHYROID HORMONE1Endocrinology, 1981
- Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat.Journal of Clinical Investigation, 1981
- Chapter 28 Cyclic AMP in Regulation of Renal Transport: Some Basic Unsolved QuestionsPublished by Elsevier ,1980
- Renal Handling of PhosphatePublished by Springer Nature ,1980
- Redox function in plasma membranesBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1978
- Amino acid transport systems in animal cells: Interrelations and energizationJournal of Supramolecular Structure, 1977
- Parathyroid Harmone, 3′5′ AMP, Ca ++ , and Renal GluconeogenesisProceedings of the National Academy of Sciences, 1970