THE EFFECT OF OVERDOSES OF IRRADIATED ERGOSTEROL, ADMINISTERED FOR APPROXIMATELY TWO MONTHS, ON THE COMPOSITION AND STRUCTURE OF THE BONES OF RATS

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Abstract
To 9 rats aged 68-138 days at the beginning of the experiment sufficient irradiated ergosterol (IE) was given to produce death but only after 6-8 wks. The femora of these rats were very porous owing to the removal of organic and inorganic matrix, as a result of osteoclastic activity. Apparently the action of IE when given in large doses is not a simple withdrawal of Ca salts from the bone. Large but non-toxic doses of IE given to 17 young rats on a diet low in Ca did not materially change the absolute amount of ash in the femora. The relative amounts of ash were greater in the animals receiving IE than in control animals due to the development of osteoid tissue in the bones of the latter. In the group of young rats the blood Ca remained about normal in the animals receiving vitamin D, but fell to less than 7 mgm. per 100 cc. in the animals given the basal diet only.

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