Effects of Cortisone Acetate on Fluid and Electrolyte Balance in Normal Rabbits.

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Abstract
1. External balance studies for sodium and potassium and serial isotopic determinations of the exchangeable potassium content were made in 2 groups of normal male rabbits which were given, respectively, 4 mg of cortisone acetate daily for 2 weeks and 25 mg daily for 3 weeks. The administration of 4 mg daily resulted in an increase in body weight and a reduction in serum sodium concentration within 7 days; both serum sodium and serum potassium concentrations were increased in 14 days. One week after discontinuation of cortisone, the animals were in negative sodium balance. The administration of 25 mg daily resulted in a negative sodium and potassium balance with an increase in serum sodium concentration within 7 days. At 21 days, body weight and exchangeable potassium content were reduced. 2. The results indicate that the response of normal rabbits to cortisone acetate varies with the size of the dose and with the length of the period of administration. The results suggest that the earliest change to occur following the administration of a small dose daily was a retention of water in the extracellular fluid compartment; with continued administration of this dose, water was redistributed into the intracellular phase. The administration of a larger dose of cortisone daily resulted in depletion of the body's store of potassium.

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