Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease.
Open Access
- 1 December 1980
- Vol. 21 (12) , 1030-1034
- https://doi.org/10.1136/gut.21.12.1030
Abstract
The serum concentrations of the complement inactivators C1INH, C3bINA and beta 1H have been determined in patients with ulcerative colitis and Crohn's disease and their correlation with C3 and properdin factor B examined. The incidence of immunoconglutinins (1K) in these patients was investigated. Raised serum concentrations of C1INH and C3bINA have been found in patients with active disease, but no significant alteration was found in serum concentration of beta 1H. An increasing incidence of positive 1K titres was found with increased length of disease history. These results suggest continuing complement activation in these diseases.Keywords
This publication has 24 references indexed in Scilit:
- Clq metabolism in ulcerative colitis and Crohn's disease.Gut, 1979
- Activity of the alternative pathway of complementin the newborn infantThe Journal of Pediatrics, 1978
- Humoral immune system in inflammatory bowel disease: I. Complement levels.Gut, 1977
- Short-term course and prognosis of Crohn's diseaseGut, 1974
- EVIDENCE OF CYTOTOXICITY IN ULCERATIVE COLITIS FROM IMMUNOFLUORESCENT STAINING OF THE RECTAL MUCOSAThe Lancet, 1974
- EVIDENCE FOR COMPLEMENT-BINDING IMMUNE COMPLEXES IN ADULT CŒLIAC DISEASE, CROHN'S DISEASE, AND ULCERATIVE COLITISThe Lancet, 1973
- Decreased Properdin Activity in Acute GlomerulonephritisInternational Archives of Allergy and Immunology, 1969
- INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDE: CONSUMPTION OF EACH OF THE SIX TERMINAL COMPLEMENT COMPONENTSThe Journal of Experimental Medicine, 1968
- Positive Epinephrine Skin Test for “Circulating Endotoxin” in Inflammatory Disease of the IntestineAmerican Journal of Clinical Pathology, 1965
- Cortisone in Ulcerative ColitisBMJ, 1955