Induction of growth in kidney epithelial cells in culture by Na+.

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Abstract
The role of Na+ in the regulation of cell growth was examined in quiescent, high-density cultures of kidney epithelial cells of the [African green monkey] BSC-1 line. The addition of NaCl to the medium increased the number of cells initiating DNA synthesis in a concentration-dependent manner after serum stimulation. In the presence of added NaCl, cells in confluent cultures grew to high density at an increased rate, whereas growth in space cultures was retarded. Apparently, in the presence of serum, Na+ can act as a mediator of the events that initiate cell proliferation.