Action of some metal ions on yeast chromosomes.

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Abstract
The effects of metal compounds on nuclear mitotic cross-over, mitotic gene conversion and reversion were studied in a diploid yeast, S. cerevisiae strain D7. All metal compounds used in these experiments had cell killing effects at concentrations of 10-2 to 10-4 M. These metal compounds were classified into 2 groups according to their effects of strain D7. Cr, Ar, Cd, Co and Ni compounds induced mitotic cross-over and gene conversion. Pb, Hg and Zn compounds induced mitotic gene conversion at only limited frequencies but the frequency of mitotic cross-over among the convertants was significantly higher than in the control. No increase in reversion frequencies was observed with these compounds.

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