THE INFLUENCE OF THE THYROID ON PREGNANCY AND PARTURITION IN THE RABBIT

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Abstract
The ovarian changes in the rabbit following complete thyroidectomy have been reported in a previous communication [Chu, 1944]. It was pointed out that in the absence of the thyroid gland, hypertrophy of the follicular apparatus resulted from the increased production of follicle-stimulating hormone, but that the life span of the corpus luteum did not seem to be shortened although the pituitary luteinizing hormone was diminished. As a result of follicular hypertrophy, the oestrogen in the circulation would be increased. Since such an increase over a certain physiological level would disturb the course of pregnancy [Parkes, Dodds & Noble, 1938; Heckel & Allen, 1938; and others], an investigation into the relationship between the thyroid gland and gestation in the rabbit was undertaken. MATERIAL AND METHOD The experimental animals were divided into four groups: (1) normal rabbits were rendered pregnant and were thyroidectomized at various times during gestation; (2) pregnancy was induced

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