A cost-utility analysis of antenatal screening to prevent congenital rubella syndrome
- 17 December 2009
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 138 (8) , 1172-1184
- https://doi.org/10.1017/s0950268809991336
Abstract
SUMMARY In low vaccination coverage regions (LVR) in The Netherlands people often reject participation in the National Immunization Programme for religious reasons. During a rubella epidemic in 2004–2005, 32 pregnant women were notified with rubella, and 11 babies were born with defects related to maternal infection. This study presents a cost-utility analysis of a screening and vaccination programme for rubella focusing on three scenarios: (1) screening non-vaccinated pregnant women in LVR; (2) screening all pregnant women in LVR; (3) screening all non-vaccinated pregnant women in The Netherlands (including pregnant first-generation non-Western immigrant women). Cost-utility was estimated over a 16-year period which included two rubella outbreaks. Observed complications from the 2004–2005 epidemic were used to estimate average cost savings and quality-adjusted life-years (QALY) gained. The programme would be cost-effective (€1100/QALY gained) when assuming an acceptability of vaccination of 20% in women belonging to orthodox protestant risk groups.Keywords
This publication has 13 references indexed in Scilit:
- Rubella Outbreak in the Netherlands, 2004–2005The Pediatric Infectious Disease Journal, 2009
- Feasibility of a rubella screening and vaccination programme for unvaccinated young womenEpidemiology and Infection, 2009
- Calculating QALYs, comparing QALY and DALY calculationsHealth Policy and Planning, 2006
- Disability weights for comorbidity and their influence on Health-adjusted Life ExpectancyPopulation Health Metrics, 2006
- RubellaThe Lancet, 2004
- Poliovirus Circulation among Schoolchildren during the Early Phase of the 1992–1993 Poliomyelitis Outbreak in The NetherlandsThe Journal of Infectious Diseases, 2001
- Measles Outbreak in a Community with Very Low Vaccine Coverage, the NetherlandsEmerging Infectious Diseases, 2001
- Measles Outbreak in a Community with Very Low Vaccine Coverage, the NetherlandsEmerging Infectious Diseases, 2001
- A national burden of disease calculation: Dutch disability-adjusted life-years. Dutch Burden of Disease GroupAmerican Journal of Public Health, 2000
- Prevalence of antibodies against rubella virus in the Netherlands 9 years after changing from selective to mass vaccinationEpidemiology and Infection, 1999