Mitochondrial biogenesis: Which part of “NO” do we understand?
- 19 May 2003
- Vol. 25 (6) , 538-541
- https://doi.org/10.1002/bies.10298
Abstract
A recent paper by Nisoli et al.1 provides the first evidence that elevated levels of nitric oxide (NO) stimulate mitochondrial biogenesis in a number of cell lines via a soluble guanylate‐cyclase‐dependent signaling pathway that activates PGC1α (peroxisome proliferator‐activated receptor γ coactivator‐1α), a master regulator of mitochondrial content. These results raise intriguing possibilities for a role of NO in modulating mitochondrial content in response to physiological stimuli such as exercise or cold exposure. However, whether this signaling cascade represents a widespread mechanism by which mammalian tissues regulate mitochondrial content, and how it might integrate with other pathways that control PGC1α expression, remain unclear. BioEssays 25:538–541, 2003.Keywords
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