gp96-Peptide Vaccination of Mice against Intracellular Bacteria
- 1 June 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (6) , 4164-7
- https://doi.org/10.1128/iai.69.6.4164-4167.2001
Abstract
This work demonstrates that gp96 preparations isolated from cells infected with intracellular bacteria induce cytotoxic T-lymphocyte responses and confer protection. Our findings extend previous reports on the immunogenicity of gp96-associated peptides to antigens derived from intracellular bacteria. Immunization with gp96 may therefore represent a promising vaccination strategy against bacterial pathogens.Keywords
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