DESCRIPTION OF A SUICIDE TECHNIQUE INVITRO FOR GRANULOCYTIC STEM-CELLS (CFUC) BY HYDROXYUREA ON NORMAL HUMAN BONE-MARROW

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (9-10) , 349-353
Abstract
It was possible, by studying 15 normal human bone marrow samples, to develop a technique for the suicide effect in vitro by hydroxyurea (HU), applied to human granulocytic stem cells (CFUc). This study suggests a contact time of medullary cells from 60-80 min in the presence of a hydroxyurea concentration of 6 mM/106 cells/ml in vitro. Preliminary results concerning the clusters are discussed.